Crystal structure of the mammalian Grb2 adaptor.

  title={Crystal structure of the mammalian Grb2 adaptor.},
  author={Sebastian Maignan and Jacques Guilloteau and Nadine Fromage and B Arnoux and J{\'e}r{\^o}me Becquart and Arnaud Ducruix},
  volume={268 5208},
The mammalian growth factor receptor-binding protein Grb2 is an adaptor that mediates activation of guanine nucleotide exchange on Ras. Grb2 binds to the receptor through its SH2 domain and to the carboxyl-terminal domain of Son of sevenless through its two SH3 domains. It is thus a key element in the signal transduction pathway. The crystal structure of Grb2 was determined to 3.1 angstrom resolution. The asymmetric unit is composed of an embedded dimer. The interlaced junctions between the SH2… CONTINUE READING