Crystal structure of the major peanut allergen Ara h 1.

@article{Cabanos2011CrystalSO,
  title={Crystal structure of the major peanut allergen Ara h 1.},
  author={Cerrone S. Cabanos and Hiroyuki Urabe and Mary Rose Gecolea Tandang-Silvas and Shigeru Utsumi and Bunzo Mikami and Nobuyuki Maruyama},
  journal={Molecular immunology},
  year={2011},
  volume={49 1-2},
  pages={115-23}
}
Ara h 1, a 7S globulin, is one of the three major peanut allergens. We previously reported the crystallization of the core region of recombinant Ara h 1. Here, we present the crystal structure of the Ara h 1 core at a resolution of 2.43 Å. We also assayed the Ara h 1 core thermal stability and compared its final structure against other 7S globulins. The Ara h 1 core has a thermal denaturation temperature of 88.3°C and a structure that is very similar to other 7S globulins. Previously identified… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 12 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 43 references

Crystal structures of recombinant and native soybean betaconglycinin beta homotrimers

  • N. Maruyama, T. Katsube, +5 authors S. Utsumi
  • Eur . J . Biochem .
  • 2001
Highly Influential
2 Excerpts

Crystallization and preliminary X - ray analysis of the major peanut allergen Ara h 1 core region

  • E. C. Jong, M. Van Zijverden, S. Spanhaak, S. J. Koppelman, H. Pellegrom
  • Acta Crystallogr . F : Struct . Biol . Cryst…
  • 2010

Characteri - zation and crystallography of recombinant 7 S globulins of Adzuki bean and structure – function relationships with 7 S globulins of various crops

  • J. Grundy, S. Matthews, B. Bateman, T. Dean, S. H. Arshad
  • J . Agric . Food Chem .
  • 2008

Deter - mination of pepsinsusceptible and pepsinresistant epitopes in native and heat - treated peanut allergen Ara h 1

  • E. L. Boxtel, S. J. Koppelman, L. A. van den Broek, H. Gruppen
  • J . Agric . Food Chem .
  • 2008

Anaphylaxis to foods

  • P. Rouge, R. Culerrier, V. Sabatier, C. Granier, F. Rance, A. Barre
  • Pediatr . Allergy Immunol .
  • 2007

Similar Papers

Loading similar papers…