Crystal structure of the major peanut allergen Ara h 1.

  title={Crystal structure of the major peanut allergen Ara h 1.},
  author={Cerrone S. Cabanos and Hiroyuki Urabe and Mary Rose Gecolea Tandang-Silvas and Shigeru Utsumi and Bunzo Mikami and Nobuyuki Maruyama},
  journal={Molecular immunology},
  volume={49 1-2},
Ara h 1, a 7S globulin, is one of the three major peanut allergens. We previously reported the crystallization of the core region of recombinant Ara h 1. Here, we present the crystal structure of the Ara h 1 core at a resolution of 2.43 Å. We also assayed the Ara h 1 core thermal stability and compared its final structure against other 7S globulins. The Ara h 1 core has a thermal denaturation temperature of 88.3°C and a structure that is very similar to other 7S globulins. Previously identified… CONTINUE READING

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