Crystal structure of the ligand-bound glucagon-like peptide-1 receptor extracellular domain.

  title={Crystal structure of the ligand-bound glucagon-like peptide-1 receptor extracellular domain.},
  author={Steffen Runge and Henning Th\ogersen and Kjeld Madsen and Jesper F Lau and Rainer Rudolph},
  journal={The Journal of biological chemistry},
  volume={283 17},
The glucagon-like peptide-1 receptor (GLP-1R) belongs to Family B1 of the seven-transmembrane G protein-coupled receptors, and its natural agonist ligand is the peptide hormone glucagon-like peptide-1 (GLP-1). GLP-1 is involved in glucose homeostasis, and activation of GLP-1R in the plasma membrane of pancreatic beta-cells potentiates glucose-dependent insulin secretion. The N-terminal extracellular domain (nGLP-1R) is an important ligand binding domain that binds GLP-1 and the homologous… CONTINUE READING


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Crystal Structure of the GLP-1R Extracellular Domain APRIL

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