Crystal structure of the lambda repressor C-terminal domain provides a model for cooperative operator binding.

@article{Bell2000CrystalSO,
  title={Crystal structure of the lambda repressor C-terminal domain provides a model for cooperative operator binding.},
  author={Charles E. Bell and Paolo Frescura and Ann Hochschild and Mitchell Lewis},
  journal={Cell},
  year={2000},
  volume={101 7},
  pages={801-11}
}
Interactions between transcription factors bound to separate operator sites commonly play an important role in gene regulation by mediating cooperative binding to the DNA. However, few detailed structural models for understanding the molecular basis of such cooperativity are available. The c1 repressor of bacteriophage lambda is a classic example of a protein that binds to its operator sites cooperatively. The C-terminal domain of the repressor mediates dimerization as well as a dimer-dimer… CONTINUE READING

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