Crystal structure of the incretin-bound extracellular domain of a G protein-coupled receptor.

@article{Parthier2007CrystalSO,
  title={Crystal structure of the incretin-bound extracellular domain of a G protein-coupled receptor.},
  author={Christoph Parthier and Martin Kleinschmidt and Piotr Neumann and Rainer Rudolph and Susanne Manhart and Dagmar Schlenzig and J{\"o}rg Fangh{\"a}nel and J Rahfeld and Hans-Ulrich Demuth and Milton T Stubbs},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2007},
  volume={104 35},
  pages={13942-7}
}
Incretins, endogenous polypeptide hormones released in response to food intake, potentiate insulin secretion from pancreatic beta cells after oral glucose ingestion (the incretin effect). This response is signaled by the two peptide hormones glucose-dependent insulinotropic polypeptide (GIP) (also known as gastric inhibitory polypeptide) and glucagon-like peptide 1 through binding and activation of their cognate class 2 G protein-coupled receptors (GPCRs). Because the incretin effect is lost or… CONTINUE READING
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