Crystal structure of the human nuclear cap binding complex.


The heterodimeric nuclear cap binding complex (CBC) binds to 5'-capped polymerase II transcripts. It enhances the efficiency of several mRNA maturation steps and is essential for U snRNA nuclear export in multicellular eukaryotes. The 2A crystal structure of human CBC shows that the large subunit, CBP80, comprises three domains, each containing consecutive… (More)


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@article{Mazza2001CrystalSO, title={Crystal structure of the human nuclear cap binding complex.}, author={Catherine Jane Mazza and Mutsuhito Ohno and Armin Segref and Iain W Mattaj and Stephen Cusack}, journal={Molecular cell}, year={2001}, volume={8 2}, pages={383-96} }