Crystal structure of the human lamin A coil 2B dimer: implications for the head-to-tail association of nuclear lamins.

@article{Strelkov2004CrystalSO,
  title={Crystal structure of the human lamin A coil 2B dimer: implications for the head-to-tail association of nuclear lamins.},
  author={Sergei V. Strelkov and Jens Schumacher and Peter Burkhard and Ueli Aebi and Harald Herrmann},
  journal={Journal of molecular biology},
  year={2004},
  volume={343 4},
  pages={1067-80}
}
Nuclear intermediate filaments (IFs) are made from fibrous proteins termed lamins that assemble, in association with several transmembrane proteins of the inner nuclear membrane and an unknown number of chromatin proteins, into a filamentous scaffold called the nuclear lamina. In man, three types of lamins with significant sequence identity, i.e. lamin A/C, lamin B1 and B2, are expressed. The molecular characteristics of the filaments they form and the details of the assembly mechanism are… CONTINUE READING

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