Crystal structure of the human adenovirus proteinase with its 11 amino acid cofactor.

@article{Ding1996CrystalSO,
  title={Crystal structure of the human adenovirus proteinase with its 11 amino acid cofactor.},
  author={Jianzhong Ding and William J. McGrath and Robert M. Sweet and Walter F. Mangel},
  journal={The EMBO journal},
  year={1996},
  volume={15 8},
  pages={1778-83}
}
The three-dimensional structure of the human adenovirus-2 proteinase complexed with its 11 amino acid cofactor, pVIc, was determined at 2.6 A resolution by X-ray crystallographic analysis. The fold of this protein has not been seen before. However, it represents an example of either subtly divergent or powerfully convergent evolution, because the active site contains a Cys-His-Glu triplet and oxyanion hole in an arrangement similar to that in papain. Thus, the adenovirus proteinase represents a… CONTINUE READING