Crystal structure of the human TbetaR2 ectodomain--TGF-beta3 complex.

  title={Crystal structure of the human TbetaR2 ectodomain--TGF-beta3 complex.},
  author={P John Hart and Shashank Deep and Alexander Bryan Taylor and Zhanyong Shu and Cynthia S. Hinck and Andrew P. Hinck},
  journal={Nature structural biology},
  volume={9 3},
Transforming growth factor-beta (TGF-beta) is the prototype of a large family of structurally related cytokines that play key roles in maintaining cellular homeostasis by signaling through two classes of functionally distinct Ser/Thr kinase receptors, designated as type I and type II. TGF-beta initiates receptor assembly by binding with high affinity to the type II receptor. Here, we present the 2.15 A crystal structure of the extracellular ligand-binding domain of the human TGF-beta type II… CONTINUE READING