Crystal structure of the human K2P TRAAK, a lipid- and mechano-sensitive K+ ion channel.

@article{Brohawn2012CrystalSO,
  title={Crystal structure of the human K2P TRAAK, a lipid- and mechano-sensitive K+ ion channel.},
  author={Stephen G. Brohawn and Josefina del M{\'a}rmol and Roderick MacKinnon},
  journal={Science},
  year={2012},
  volume={335 6067},
  pages={
          436-41
        }
}
TRAAK channels, members of the two-pore domain K(+) (potassium ion) channel family K2P, are expressed almost exclusively in the nervous system and control the resting membrane potential. Their gating is sensitive to polyunsaturated fatty acids, mechanical deformation of the membrane, and temperature changes. Physiologically, these channels appear to control the noxious input threshold for temperature and pressure sensitivity in dorsal root ganglia neurons. We present the crystal structure of… CONTINUE READING
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