Crystal structure of the human AAA+ protein RuvBL1.

  title={Crystal structure of the human AAA+ protein RuvBL1.},
  author={Pedro Moreno Mat{\'i}as and Sabine Gorynia and Peter Donner and Maria Arm{\'e}nia Carrondo},
  journal={The Journal of biological chemistry},
  volume={281 50},
RuvBL1 is an evolutionarily highly conserved eukaryotic protein belonging to the AAA(+)-family of ATPases (ATPase associated with diverse cellular activities). It plays important roles in essential signaling pathways such as the c-Myc and Wnt pathways in chromatin remodeling, transcriptional and developmental regulation, and DNA repair and apoptosis. Herein we present the three-dimensional structure of the selenomethionine variant of human RuvBL1 refined using diffraction data to 2.2A of… CONTINUE READING
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