Crystal structure of the human β2 adrenergic G-protein-coupled receptor

@article{Rasmussen2007CrystalSO,
  title={Crystal structure of the human $\beta$2 adrenergic G-protein-coupled receptor},
  author={S{\o}ren G. F. Rasmussen and Hee-Jung Choi and Daniel M. Rosenbaum and Tong Sun Kobilka and Foon Sun Thian and Patricia C. Edwards and Manfred Burghammer and Venkata R. P. Ratnala and Ruslan Sanishvili and Robert F. Fischetti and Gebhard F. X. Schertler and William I. Weis and Brian K. Kobilka},
  journal={Nature},
  year={2007},
  volume={450},
  pages={383-387}
}
Structural analysis of G-protein-coupled receptors (GPCRs) for hormones and neurotransmitters has been hindered by their low natural abundance, inherent structural flexibility, and instability in detergent solutions. [...] Key Result These differences may be responsible for the relatively high basal activity and structural instability of the β2AR, and contribute to the challenges in obtaining diffraction-quality crystals of non-rhodopsin GPCRs.Expand

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