Crystal structure of the human β2 adrenergic G-protein-coupled receptor

@article{Rasmussen2007CrystalSO,
  title={Crystal structure of the human β2 adrenergic G-protein-coupled receptor},
  author={S\oren G. F. Rasmussen and Hee Jung Choi and Daniel M Rosenbaum and Tong Sun Kobilka and Foon Sun Thian and Patricia C. Edwards and Manfred C Burghammer and Venkata R. P. Ratnala and Ruslan Sanishvili and Robert F. Fischetti and Gebhard F. X. Schertler and William I Weis and Brian K. Kobilka},
  journal={Nature},
  year={2007},
  volume={450},
  pages={383-387}
}
Structural analysis of G-protein-coupled receptors (GPCRs) for hormones and neurotransmitters has been hindered by their low natural abundance, inherent structural flexibility, and instability in detergent solutions. Here we report a structure of the human β2 adrenoceptor (β2AR), which was crystallized in a lipid environment when bound to an inverse agonist and in complex with a Fab that binds to the third intracellular loop. Diffraction data were obtained by high-brilliance… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.

Explore Further: Topics Discussed in This Paper

Citations

Publications citing this paper.
Showing 1-10 of 148 extracted citations

Molecular Mechanisms of GPCR Signaling: A Structural Perspective

International journal of molecular sciences • 2017
View 4 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 56 references

A monoclonal antibody for G protein coupled receptor crystallography

Day, W P.
Nature Methods doi:10.1038/nmeth1112 • 2007

Crystal structure of a thermally stable rhodopsin

J Standfuss
mutant. J. Mol. Biol • 2007

Crystal structure of a thermally stable rhodopsin mutant

R. J. Lefkowitz
J . Mol . Biol . • 2007

Role of group-conserved residues in the helical core of beta2-adrenergic receptor.

Proceedings of the National Academy of Sciences of the United States of America • 2007

Solving structures of protein complexes by molecular replacement with Phaser

Acta crystallographica. Section D, Biological crystallography • 2007

insights from fluorescence resonance energy transfer studies

Granier, S. et al. Structure, conformational changes in the C-terminal domain of the b2-adrenoceptor
J. Biol. Chem. 282, 13895–13905 • 2007

Similar Papers

Loading similar papers…