Crystal structure of the human β2 adrenergic G-protein-coupled receptor

  title={Crystal structure of the human β2 adrenergic G-protein-coupled receptor},
  author={S\oren G. F. Rasmussen and Hee Jung Choi and Daniel M Rosenbaum and Tong Sun Kobilka and Foon Sun Thian and Patricia C. Edwards and Manfred C Burghammer and Venkata R. P. Ratnala and Ruslan Sanishvili and Robert F. Fischetti and Gebhard F. X. Schertler and William I Weis and Brian K. Kobilka},
Structural analysis of G-protein-coupled receptors (GPCRs) for hormones and neurotransmitters has been hindered by their low natural abundance, inherent structural flexibility, and instability in detergent solutions. Here we report a structure of the human β2 adrenoceptor (β2AR), which was crystallized in a lipid environment when bound to an inverse agonist and in complex with a Fab that binds to the third intracellular loop. Diffraction data were obtained by high-brilliance… CONTINUE READING

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