Crystal structure of the hCASK PDZ domain reveals the structural basis of class II PDZ domain target recognition

@article{Daniels1998CrystalSO,
  title={Crystal structure of the hCASK PDZ domain reveals the structural basis of class II PDZ domain target recognition},
  author={Danette L Daniels and Alexandra R. Cohen and James M. Anderson and Axel T. Br{\"u}nger},
  journal={Nature Structural Biology},
  year={1998},
  volume={5},
  pages={317-325}
}
PDZ domain containing proteins assist formation of cell–cell junctions and localization of membrane protein receptors and ion channels. PDZ domains interact with the C-terminal residues of a particular target membrane protein. Based on their binding specificities and sequence homologies, PDZ domains fall into two classes. The first crystal structure of a class II PDZ domain, that of hCASK, has been solved by multi-wavelength anomalous dispersion phasing. Complex formation with the C-terminus of… CONTINUE READING

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