Crystal structure of the gephyrin-related molybdenum cofactor biosynthesis protein MogA from Escherichia coli.

@article{Liu2000CrystalSO,
  title={Crystal structure of the gephyrin-related molybdenum cofactor biosynthesis protein MogA from Escherichia coli.},
  author={Min-tsai Liu and Margot M. Wuebbens and Kasturi Rajagopalan and Hermann Schindelin},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 3},
  pages={
          1814-22
        }
}
Molybdenum cofactor (Moco) biosynthesis is an evolutionarily conserved pathway in archaea, eubacteria, and eukaryotes, including humans. Genetic deficiencies of enzymes involved in this biosynthetic pathway trigger an autosomal recessive disease with severe neurological symptoms, which usually leads to death in early childhood. The MogA protein exhibits affinity for molybdopterin, the organic component of Moco, and has been proposed to act as a molybdochelatase incorporating molybdenum into… CONTINUE READING
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