Crystal structure of the essential N-terminal domain of telomerase reverse transcriptase

@article{Jacobs2006CrystalSO,
  title={Crystal structure of the essential N-terminal domain of telomerase reverse transcriptase},
  author={Steven A. Jacobs and Elaine R. Podell and Thomas R Cech},
  journal={Nature Structural & Molecular Biology},
  year={2006},
  volume={13},
  pages={218-225}
}
Telomerase, a ribonucleoprotein enzyme, adds telomeric DNA repeats to the ends of linear chromosomes. Here we report the first high-resolution structure of any portion of the telomerase reverse transcriptase, the telomerase essential N-terminal (TEN) domain from Tetrahymena thermophila. The structure, which seems to represent a novel protein fold, shows phylogenetically conserved amino acid residues in a groove on its surface. These residues are crucial for telomerase catalytic activity, and… CONTINUE READING
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