Crystal structure of the dimeric coiled-coil domain of the cytosolic nucleic acid sensor LRRFIP1.

Abstract

LRRFIP1 binds cytoplasmic double-stranded DNA and RNA and interacts with FLI, the mammalian homolog of Drosophila flightless I, through a highly conserved 87-amino acid domain. Upon binding nucleic acid ligands, LRRFIP1 recruits and activates β-catenin, leading to the IRF3-dependent production of type I interferon. However, the molecular mechanism of… (More)
DOI: 10.1016/j.jsb.2012.10.006

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