Crystal structure of the conserved N-terminal domain of the peroxisomal matrix protein import receptor, Pex14p.

@article{Su2009CrystalSO,
  title={Crystal structure of the conserved N-terminal domain of the peroxisomal matrix protein import receptor, Pex14p.},
  author={Jian-Rong Su and Kazuki Takeda and Shigehiko Tamura and Yukio Fujiki and Kunio Miki},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2009},
  volume={106 2},
  pages={417-21}
}
Pex14p is a central component of the peroxisomal protein import machinery, in which the conserved N-terminal domain mediates dynamic interactions with other peroxins including Pex5p, Pex13p, and Pex19p. Here, we report the crystal structure of the conserved N-terminal domain of Pex14p with a three-helix bundle. A hydrophobic surface is composed of the conserved residues, of which two phenylalanine residues (Phe-35 and Phe-52) protrude to the solvent. Consequently, two putative binding pockets… CONTINUE READING
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