Crystal structure of the complex of the cyclin D-dependent kinase Cdk6 bound to the cell-cycle inhibitor p19INK4d

@article{Brotherton1998CrystalSO,
  title={Crystal structure of the complex of the cyclin D-dependent kinase Cdk6 bound to the cell-cycle inhibitor p19INK4d},
  author={Deborah H. Brotherton and Venugopal Dhanaraj and Scott Wick and Leonardo Brizuela and Peter J. Domaille and Elena V. Volyanik and Xu Xu and Emilio Parisini and Brian O Smith and Sharon J. Archer and Manuel Serrano and Stephen L. Brenner and Tom L. Blundell and Ernest D. Laue},
  journal={Nature},
  year={1998},
  volume={395},
  pages={244-250}
}
The crystal structure of the cyclin D-dependent kinase Cdk6 bound to the p19INK4d protein has been determined at 1.9 Å resolution. The results provide the first structural information for a cyclin D-dependent protein kinase and show how the INK4 family of CDK inhibitors bind. The structure indicates that the conformational changes induced by p19INK4d inhibit both productive binding of ATP and the cyclin-induced rearrangement of the kinase from an inactive to an active conformation. The… CONTINUE READING