Crystal structure of the cofactor-binding domain of the human phase II drug-metabolism enzyme UDP-glucuronosyltransferase 2B7.

@article{Miley2007CrystalSO,
  title={Crystal structure of the cofactor-binding domain of the human phase II drug-metabolism enzyme UDP-glucuronosyltransferase 2B7.},
  author={Michael J. Miley and Agnieszka K. Zielinska and Jeffrey E. Keenan and Stacie M. Bratton and Anna Radomińska-Pandya and Matthew R. Redinbo},
  journal={Journal of molecular biology},
  year={2007},
  volume={369 2},
  pages={
          498-511
        }
}
Human UDP-glucuronosyltransferases (UGT) are the dominant phase II conjugative drug metabolism enzymes that also play a central role in processing a range of endobiotic compounds. UGTs catalyze the covalent addition of glucuronic acid sugar moieties to a host of therapeutics and environmental toxins, as well as to a variety of endogenous steroids and other signaling molecules. We report the 1.8-A resolution apo crystal structure of the UDP-glucuronic acid binding domain of human UGT isoform 2B7… CONTINUE READING
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