Crystal structure of the calcium pump with a bound ATP analogue

@article{Toyoshima2004CrystalSO,
  title={Crystal structure of the calcium pump with a bound ATP analogue},
  author={Chikashi Toyoshima and Tatsuaki Mizutani},
  journal={Nature},
  year={2004},
  volume={430},
  pages={529-535}
}
P-type ATPases are ATP-powered ion pumps that establish ion concentration gradients across cell and organelle membranes. Here, we describe the crystal structure of the Ca2+ pump of skeletal muscle sarcoplasmic reticulum, a representative member of the P-type ATPase superfamily, with an ATP analogue, a Mg2+ and two Ca2+ ions in the respective binding sites. In this state, the ATP analogue reorganizes the three cytoplasmic domains (A, N and P), which are widely separated without nucleotide, by… 
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