Crystal structure of the calcium pump of sarcoplasmic reticulum at 2.6 Å resolution

  title={Crystal structure of the calcium pump of sarcoplasmic reticulum at 2.6 Å resolution},
  author={C. Toyoshima and M. Nakasako and H. Nomura and H. Ogawa},
  • C. Toyoshima, M. Nakasako, +1 author H. Ogawa
  • Published 2000
  • Chemistry, Medicine
  • Nature
  • Calcium ATPase is a member of the P-type ATPases that transport ions across the membrane against a concentration gradient. Here we have solved the crystal structure of the calcium ATPase of skeletal muscle sarcoplasmic reticulum (SERCA1a) at 2.6 Å resolution with two calcium ions bound in the transmembrane domain, which comprises ten α-helices. The two calcium ions are located side by side and are surrounded by four transmembrane helices, two of which are unwound for efficient coordination… CONTINUE READING
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