Crystal structure of the calcium pump of sarcoplasmic reticulum at 2.6 Å resolution

@article{Toyoshima2000CrystalSO,
  title={Crystal structure of the calcium pump of sarcoplasmic reticulum at 2.6 Å resolution},
  author={Chikashi Toyoshima and Masayoshi Nakasako and Hiromi Nomura and Haruo Ogawa},
  journal={Nature},
  year={2000},
  volume={405},
  pages={647-655}
}
Calcium ATPase is a member of the P-type ATPases that transport ions across the membrane against a concentration gradient. Here we have solved the crystal structure of the calcium ATPase of skeletal muscle sarcoplasmic reticulum (SERCA1a) at 2.6 Å resolution with two calcium ions bound in the transmembrane domain, which comprises ten α-helices. The two calcium ions are located side by side and are surrounded by four transmembrane helices, two of which are unwound for efficient coordination… Expand
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