Crystal structure of the beta-finger domain of Prp8 reveals analogy to ribosomal proteins.

@article{Yang2008CrystalSO,
  title={Crystal structure of the beta-finger domain of Prp8 reveals analogy to ribosomal proteins.},
  author={Kui Yang and Lingdi Zhang and Tao Xu and Annie H{\'e}roux and Rui Zhao},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2008},
  volume={105 37},
  pages={13817-22}
}
Prp8 stands out among hundreds of splicing factors as a key regulator of spliceosome activation and a potential cofactor of the splicing reaction. We present here the crystal structure of a 274-residue domain (residues 1,822-2,095) near the C terminus of Saccharomyces cerevisiae Prp8. The most striking feature of this domain is a beta-hairpin finger protruding out of the protein (hence, this domain will be referred to as the beta-finger domain), resembling many globular ribosomal proteins with… CONTINUE READING

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