Crystal structure of the anti-viral APOBEC3G catalytic domain and functional implications

@article{Holden2008CrystalSO,
  title={Crystal structure of the anti-viral APOBEC3G catalytic domain and functional implications},
  author={Lauren G. Holden and Courtney Prochnow and Y Paul Chang and Ronda Bransteitter and Linda Chelico and Udayaditya Sen and Raymond C. Stevens and Myron F. Goodman and Xiaojiang S. Chen},
  journal={Nature},
  year={2008},
  volume={456},
  pages={121-124}
}
The APOBEC family members are involved in diverse biological functions. APOBEC3G restricts the replication of human immunodeficiency virus (HIV), hepatitis B virus and retroelements by cytidine deamination on single-stranded DNA or by RNA binding. Here we report the high-resolution crystal structure of the carboxy-terminal deaminase domain of APOBEC3G (APOBEC3G-CD2) purified from Escherichia coli. The APOBEC3G-CD2 structure has a five-stranded β-sheet core that is common to all known deaminase… Expand
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