Crystal structure of the anti-viral APOBEC3G catalytic domain and functional implications

@article{Holden2008CrystalSO,
  title={Crystal structure of the anti-viral APOBEC3G catalytic domain and functional implications},
  author={Lauren G. Holden and Courtney Prochnow and Y. Paul Chang and Ronda Bransteitter and Linda Chelico and Udayaditya Sen and Raymond C. Stevens and Myron F. Goodman and Xiaojiang S. Chen},
  journal={Nature},
  year={2008},
  volume={456},
  pages={121-124}
}
The APOBEC family members are involved in diverse biological functions. APOBEC3G restricts the replication of human immunodeficiency virus (HIV), hepatitis B virus and retroelements by cytidine deamination on single-stranded DNA or by RNA binding. Here we report the high-resolution crystal structure of the carboxy-terminal deaminase domain of APOBEC3G (APOBEC3G-CD2) purified from Escherichia coli. The APOBEC3G-CD2 structure has a five-stranded β-sheet core that is common to all known deaminase… CONTINUE READING
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