Crystal structure of the amino-terminal domain of N-ethylmaleimide-sensitive fusion protein

@article{May1999CrystalSO,
  title={Crystal structure of the amino-terminal domain of N-ethylmaleimide-sensitive fusion protein},
  author={Andrew P. May and Kira M. S. Misura and Sidney W Whiteheart and William I Weis},
  journal={Nature Cell Biology},
  year={1999},
  volume={1},
  pages={175-182}
}
The cytosolic ATPase N-ethylmaleimide-sensitive fusion protein (NSF) disassembles complexes of membrane-bound proteins known as SNAREs, an activity essential for vesicular trafficking. The amino-terminal domain of NSF (NSF-N) is required for the interaction of NSF with the SNARE complex through the adaptor protein α-SNAP. The crystal structure of NSF-N reveals two subdomains linked by a single stretch of polypeptide. A polar interface between the two subdomains indicates that they can move with… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 30 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 58 references

Crystal structure of the N-terminal domain of N-ethylmaleimide sensitive factor reveals possible α-SNAP binding site and unexpected structural similarity to EfTu

R. C. Yu, R. Jahn, A. T. Brünger
1999
View 9 Excerpts
Highly Influenced

Interaction of the N-ethylmaleimide-sensitive factor with AMPA receptors

I Song
Neuron 21, • 1998
View 9 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…