Crystal structure of the alpha subunit of human translation initiation factor 2B.

@article{Hiyama2009CrystalSO,
  title={Crystal structure of the alpha subunit of human translation initiation factor 2B.},
  author={Takuya B. Hiyama and Takuhiro Ito and Hiroaki Imataka and Shigeyuki Yokoyama},
  journal={Journal of molecular biology},
  year={2009},
  volume={392 4},
  pages={
          937-51
        }
}
Eukaryotic translation initiation factor 2B (eIF2B) is the heteropentameric guanine-nucleotide exchange factor specific for eukaryotic initiation factor 2 (eIF2). Under stressed conditions, guanine-nucleotide exchange is strongly inhibited by the tight binding of phosphorylated eIF2 to eIF2B. Here, we report the crystal structure of the alpha subunit of human eIF2B at 2.65 A resolution. The eIF2Balpha structure consists of the N-terminal alpha-helical domain and the C-terminal Rossmann-fold… CONTINUE READING

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