Crystal structure of the V-region of Streptococcus mutans antigen I/II at 2.4 A resolution suggests a sugar preformed binding site.

@article{TrofferCharlier2002CrystalSO,
  title={Crystal structure of the V-region of Streptococcus mutans antigen I/II at 2.4 A resolution suggests a sugar preformed binding site.},
  author={Nathalie Troffer-Charlier and Jo{\"e}lle Ogier and Dino Moras and Jean Cavarelli},
  journal={Journal of molecular biology},
  year={2002},
  volume={318 1},
  pages={179-88}
}
Antigens I/II are large multifunctional adhesins from oral viridans streptococci that exert immunomodulatory effects on human cells and play important roles in inflammatory disorders. Among them, Streptococcus mutans plays a major role in the initiation of dental caries. The structure of the V-region (SrV+, residues 464-840) of the antigen I/II of S. mutans has been determined using the multiwavelength anomalous diffraction phasing technique with seleno-methionine-substituted recombinant… CONTINUE READING
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