Crystal structure of the SarS protein from Staphylococcus aureus.

  title={Crystal structure of the SarS protein from Staphylococcus aureus.},
  author={Ronggui Li and Adhar C. Manna and Shaodong Dai and Ambrose L. Cheung and Gongyi Zhang},
  journal={Journal of bacteriology},
  volume={185 14},
The expression of virulence determinants in Staphylococcus aureus is controlled by global regulatory loci (e.g., sarA and agr). One of these determinants, protein A (spa), is activated by sarS, which encodes a 250-residue DNA-binding protein. Genetic analysis indicated that the agr locus likely mediates spa repression by suppressing the transcription of sarS. Contrary to SarA and SarR, which require homodimer formation for proper function, SarS is unusual within the SarA protein family in that… CONTINUE READING
10 Extracted Citations
36 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 10 extracted citations

Referenced Papers

Publications referenced by this paper.
Showing 1-10 of 36 references

Do SarA and SarR possess similar structures

  • A. L. Cheung, G. Zhang
  • Trends Microbiol
  • 2001

Similar Papers

Loading similar papers…