Crystal structure of the Leishmania major peroxidase-cytochrome c complex.

  title={Crystal structure of the Leishmania major peroxidase-cytochrome c complex.},
  author={Victoria S Jasion and Tzanko Doukov and Stephanie Hai Pineda and Huiying Li and Thomas L Poulos},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={109 45},
The causative agent of leishmaniasis is the protozoan parasite Leishmania major. Part of the host protective mechanism is the production of reactive oxygen species including hydrogen peroxide. In response, L. major produces a peroxidase, L. major peroxidase (LmP), that helps to protect the parasite from oxidative stress. LmP is a heme peroxidase that catalyzes the peroxidation of mitochondrial cytochrome c. We have determined the crystal structure of LmP in a complex with its substrate, L… CONTINUE READING


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