Crystal structure of the Lassa virus nucleoprotein-RNA complex reveals a gating mechanism for RNA binding.

  title={Crystal structure of the Lassa virus nucleoprotein-RNA complex reveals a gating mechanism for RNA binding.},
  author={Kathryn M Hastie and Tong Liu and Sheng Li and Liam B King and Nhi Ngo and Michelle A Zandonatti and Virgil L. Woods and Juan C de la Torre and Erica Ollmann Saphire},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={108 48},
Arenaviruses cause disease in industrialized and developing nations alike. Among them, the hemorrhagic fever virus Lassa is responsible for ~300,000-500,000 infections/y in Western Africa. The arenavirus nucleoprotein (NP) forms the protein scaffold of the genomic ribonucleoprotein complexes and is critical for transcription and replication of the viral genome. Here, we present crystal structures of the RNA-binding domain of Lassa virus NP in complex with ssRNA. This structure shows, in… CONTINUE READING


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