Crystal structure of the HCV IRES central domain reveals strategy for start-codon positioning.

@article{Berry2011CrystalSO,
  title={Crystal structure of the HCV IRES central domain reveals strategy for start-codon positioning.},
  author={Katherine E Berry and Shruti Waghray and Stefanie A W Mortimer and Yun Bai and Jennifer A. Doudna},
  journal={Structure},
  year={2011},
  volume={19 10},
  pages={1456-66}
}
Translation of hepatitis C viral proteins requires an internal ribosome entry site (IRES) located in the 5' untranslated region of the viral mRNA. The core domain of the hepatitis C virus (HCV) IRES contains a four-way helical junction that is integrated within a predicted pseudoknot. This domain is required for positioning the mRNA start codon correctly on the 40S ribosomal subunit during translation initiation. Here, we present the crystal structure of this RNA, revealing a complex double… CONTINUE READING

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