Crystal structure of the FERM domain of focal adhesion kinase.

  title={Crystal structure of the FERM domain of focal adhesion kinase.},
  author={Derek F.J. Ceccarelli and Hyun Kyu Song and Florence Poy and Michael D Schaller and Michael J. Eck},
  journal={The Journal of biological chemistry},
  volume={281 1},
Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase that localizes to focal adhesions in adherent cells. Through phosphorylation of proteins assembled at the cytoplasmic tails of integrins, FAK promotes signaling events that modulate cellular growth, survival, and migration. The amino-terminal region of FAK contains a region of sequence homology with band 4.1 and ezrin/radixin/moesin (ERM) proteins termed a FERM domain. FERM domains are found in a variety of signaling and cytoskeletal… CONTINUE READING


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