Crystal structure of the DNA binding domain of the heat shock transcription factor.

@article{Harrison1994CrystalSO,
  title={Crystal structure of the DNA binding domain of the heat shock transcription factor.},
  author={C. J. Harrison and Andrew Bohm and Hillary C. M. Nelson},
  journal={Science},
  year={1994},
  volume={263 5144},
  pages={224-7}
}
The structure of the DNA binding domain, determined at 1.8 angstrom resolution, contains a three-helix bundle that is capped by a four-stranded antiparallel beta sheet. This structure is a variant of the helix-turn-helix motif, typified by catabolite activator protein. In the heat shock transcription factor, the first helix of the motif (alpha 2) has an alpha-helical bulge and a proline-induced kink. The angle between the two helices of the motif (alpha 2 and alpha 3) is about 20 degrees… CONTINUE READING

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