Crystal structure of the BMP-2–BRIA ectodomain complex

@article{Kirsch2000CrystalSO,
  title={Crystal structure of the BMP-2–BRIA ectodomain complex},
  author={Thomas A Kirsch and Walter Sebald and Matthias K Dreyer},
  journal={Nature Structural Biology},
  year={2000},
  volume={7},
  pages={492-496}
}
Bone morphogenetic proteins (BMPs) belong to the large transforming growth factor-β (TGF-β) superfamily of multifunctional cytokines. BMP-2 can induce ectopic bone and cartilage formation in adult vertebrates and is involved in central steps in early embryonal development in animals. Signaling by these cytokines requires binding of two types of transmembrane serine/threonine receptor kinase chains classified as type I and type II. Here we report the crystal structure of human dimeric BMP-2 in… 

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