Crystal structure of the Awd nucleotide diphosphate kinase from Drosophila.

  title={Crystal structure of the Awd nucleotide diphosphate kinase from Drosophila.},
  author={Mohamed Chiadmi and Solange Mor{\'e}ra and Ioan Lascu and Christian Dumas and Georges Le Bras and M. Veron and Joel Janin},
  volume={1 4},
BACKGROUND Nucleotide diphosphate kinase (NDP kinase) is a phosphate transfer enzyme involved in cell regulation and in animal development. Drosophila NDP kinase is the product of the abnormal wing disc (awd) developmental gene, a point mutation in which can produce the killer of prune (K-pn) conditional lethal phenotype. The highly homologous mammalian genes control metastasis and a human NDP kinase acts as a transcription factor. RESULTS The X-ray structure of the Awd protein prepared from… CONTINUE READING

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