Crystal structure of the 14-subunit RNA polymerase I

@article{FernndezTornero2013CrystalSO,
  title={Crystal structure of the 14-subunit RNA polymerase I},
  author={Carlos Fern{\'a}ndez-Tornero and Mar{\'i}a Moreno-Morcillo and Umar Jan Rashid and Nicholas M. I. Taylor and Federico M. Ruiz and Tim Gruene and Pierre Legrand and Ulrich Steuerwald and Christoph W. M{\"u}ller},
  journal={Nature},
  year={2013},
  volume={502},
  pages={644-649}
}
Protein biosynthesis depends on the availability of ribosomes, which in turn relies on ribosomal RNA production. In eukaryotes, this process is carried out by RNA polymerase I (Pol I), a 14-subunit enzyme, the activity of which is a major determinant of cell growth. Here we present the crystal structure of Pol I from Saccharomyces cerevisiae at 3.0 Å resolution. The Pol I structure shows a compact core with a wide DNA-binding cleft and a tightly anchored stalk. An extended loop mimics the DNA… Expand
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