Crystal structure of swine major histocompatibility complex class I SLA-1 0401 and identification of 2009 pandemic swine-origin influenza A H1N1 virus cytotoxic T lymphocyte epitope peptides.

@article{Zhang2011CrystalSO,
  title={Crystal structure of swine major histocompatibility complex class I SLA-1 0401 and identification of 2009 pandemic swine-origin influenza A H1N1 virus cytotoxic T lymphocyte epitope peptides.},
  author={Nianzhi Zhang and Jianxun Qi and Sijia Feng and Feng Gao and Jun Liu and Xiaocheng Pan and Rong Chen and Qirun Li and Zhaosan Chen and Xiaoying Li and Chun Xia and G. F. Gao},
  journal={Journal of virology},
  year={2011},
  volume={85 22},
  pages={11709-24}
}
The presentation of viral epitopes to cytotoxic T lymphocytes (CTLs) by swine leukocyte antigen class I (SLA I) is crucial for swine immunity. To illustrate the structural basis of swine CTL epitope presentation, the first SLA crystal structures, SLA-1 0401, complexed with peptides derived from either 2009 pandemic H1N1 (pH1N1) swine-origin influenza A virus (S-OIV(NW9); NSDTVGWSW) or Ebola virus (Ebola(AY9); ATAAATEAY) were determined in this study. The overall peptide-SLA-1 0401 structures… CONTINUE READING

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