Crystal structure of substrate free form of glycerol dehydratase.

@article{Liao2003CrystalSO,
  title={Crystal structure of substrate free form of glycerol dehydratase.},
  author={D I Liao and Garry D Dotson and Ivan Turner and Lisa Reiss and Mark H Emptage},
  journal={Journal of inorganic biochemistry},
  year={2003},
  volume={93 1-2},
  pages={84-91}
}
Glycerol dehydratase (GDH) and diol dehydratase (DDH) are highly homologous isofunctional enzymes that catalyze the elimination of water from glycerol and 1,2-propanediol (1,2-PD) to the corresponding aldehyde via a coenzyme B(12)-dependent radical mechanism. The crystal structure of substrate free form of GDH in complex with cobalamin and K(+) has been determined at 2.5 A resolution. Its overall fold and the subunit assembly closely resemble those of DDH. Comparison of this structure and the… CONTINUE READING