Crystal structure of riboflavin synthase.

  title={Crystal structure of riboflavin synthase.},
  author={D I Liao and Zdzislaw Wawrzak and Joseph C. Calabrese and P. V. Viitanen and Douglas B. Jordan},
  volume={9 5},
BACKGROUND Riboflavin synthase catalyzes the dismutation of two molecules of 6,7-dimethyl-8-(1'-D-ribityl)-lumazine to yield riboflavin and 4-ribitylamino-5-amino-2,6-dihydroxypyrimidine. The homotrimer of 23 kDa subunits has no cofactor requirements for catalysis. The enzyme is nonexistent in humans and is an attractive target for antimicrobial agents of organisms whose pathogenicity depends on their ability to biosynthesize riboflavin. RESULTS The first three-dimensional structure of the… CONTINUE READING


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