Crystal structure of pyridoxal kinase in complex with roscovitine and derivatives.

  title={Crystal structure of pyridoxal kinase in complex with roscovitine and derivatives.},
  author={Lin Tang and Ming-hui Li and Peng Cao and Feng Wang and Wen-rui Chang and St{\'e}phane Bach and Jens Reinhardt and Yoan Ferandin and Herv{\'e} Galons and Yongqin Wan and Nathanael Gray and Laurent Meijer and Tao Jiang and Dong-cai Liang},
  journal={The Journal of biological chemistry},
  volume={280 35},
Pyridoxal kinase (PDXK) catalyzes the phosphorylation of pyridoxal, pyridoxamine, and pyridoxine in the presence of ATP and Zn2+. This constitutes an essential step in the synthesis of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6, a cofactor for over 140 enzymes. (R)-Roscovitine (CYC202, Seliciclib) is a relatively selective inhibitor of cyclin-dependent kinases (CDKs), currently evaluated for the treatment of cancers, neurodegenerative disorders, renal diseases, and several… CONTINUE READING


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