Crystal structure of prostate-specific membrane antigen, a tumor marker and peptidase.

@article{Davis2005CrystalSO,
  title={Crystal structure of prostate-specific membrane antigen, a tumor marker and peptidase.},
  author={Mindy I. Davis and Melanie J. Bennett and Leonard M. Thomas and Pamela J. Bjorkman},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2005},
  volume={102 17},
  pages={
          5981-6
        }
}
Prostate-specific membrane antigen (PSMA) is highly expressed in prostate cancer cells and nonprostatic solid tumor neovasculature and is a target for anticancer imaging and therapeutic agents. PSMA acts as a glutamate carboxypeptidase (GCPII) on small molecule substrates, including folate, the anticancer drug methotrexate, and the neuropeptide N-acetyl-l-aspartyl-l-glutamate. Here we present the 3.5-A crystal structure of the PSMA ectodomain, which reveals a homodimer with structural… CONTINUE READING

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