Crystal structure of peroxiredoxin from Aeropyrum pernix K1 complexed with its substrate, hydrogen peroxide.

@article{Nakamura2010CrystalSO,
  title={Crystal structure of peroxiredoxin from Aeropyrum pernix K1 complexed with its substrate, hydrogen peroxide.},
  author={Tsutomu Usui-gun Nakamura and Y. Kado and Takafumi Yamaguchi and Hiroyoshi Matsumura and Katsuhiko Ishikawa and Tsuyoshi Inoue},
  journal={Journal of biochemistry},
  year={2010},
  volume={147 1},
  pages={
          109-15
        }
}
Peroxiredoxin (Prx) reduces hydrogen peroxide and alkyl peroxides to water and corresponding alcohols, respectively. The reaction is dependent on a peroxidatic cysteine, whose sulphur atom nucleophilically attacks one of the oxygen atoms of the peroxide substrate. In spite of the many structural studies that have been carried out on this reaction, the tertiary structure of the hydrogen peroxide-bound form of Prx has not been elucidated. In this paper, we report the crystal structure of Prx from… CONTINUE READING
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Multiple Functions and Regulation of Mammalian Peroxiredoxins.

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