Crystal structure of pentaerythritol tetranitrate reductase: "flipped" binding geometries for steroid substrates in different redox states of the enzyme.

@article{Barna2001CrystalSO,
  title={Crystal structure of pentaerythritol tetranitrate reductase: "flipped" binding geometries for steroid substrates in different redox states of the enzyme.},
  author={Ter{\'e}z Barna and Huma Khan and Neil C Bruce and Igor Barsukov and Nigel S. Scrutton and Peter C E Moody},
  journal={Journal of molecular biology},
  year={2001},
  volume={310 2},
  pages={433-47}
}
Pentaerythritol tetranitrate reductase (PETN reductase) degrades high explosive molecules including nitrate esters, nitroaromatics and cyclic triazine compounds. The enzyme also binds a variety of cyclic enones, including steroids; some steroids act as substrates whilst others are inhibitors. Understanding the basis of reactivity with cyclic enones requires structural information for the enzyme and key complexes formed with steroid substrates and inhibitors. The crystal structure of oxidised… CONTINUE READING