Crystal structure of parallel quadruplexes from human telomeric DNA

@article{Parkinson2002CrystalSO,
  title={Crystal structure of parallel quadruplexes from human telomeric DNA},
  author={Gary N Parkinson and Michael P H Lee and Stephen Neidle},
  journal={Nature},
  year={2002},
  volume={417},
  pages={876-880}
}
Telomeric ends of chromosomes, which comprise noncoding repeat sequences of guanine-rich DNA, are fundamental in protecting the cell from recombination and degradation. Disruption of telomere maintenance leads to eventual cell death, which can be exploited for therapeutic intervention in cancer. Telomeric DNA sequences can form four-stranded (quadruplex) structures, which may be involved in the structure of telomere ends. Here we describe the crystal structure of a quadruplex formed from four… 
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TLDR
This review is an attempt to summarize the rapidly evolving literature exploring the amazing polymorphism of G-quadruplexes, and understanding their structure-specific-recognition and biological relevance, keeping in mind that G-tetraplexes are not only important drug targets, but may also act as gene regulatory elements.
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