Crystal structure of parallel quadruplexes from human telomeric DNA

@article{Parkinson2002CrystalSO,
  title={Crystal structure of parallel quadruplexes from human telomeric DNA},
  author={G. Parkinson and M. Lee and S. Neidle},
  journal={Nature},
  year={2002},
  volume={417},
  pages={876-880}
}
  • G. Parkinson, M. Lee, S. Neidle
  • Published 2002
  • Physics, Medicine
  • Nature
  • Telomeric ends of chromosomes, which comprise noncoding repeat sequences of guanine-rich DNA, are fundamental in protecting the cell from recombination and degradation. Disruption of telomere maintenance leads to eventual cell death, which can be exploited for therapeutic intervention in cancer. Telomeric DNA sequences can form four-stranded (quadruplex) structures, which may be involved in the structure of telomere ends. Here we describe the crystal structure of a quadruplex formed from four… CONTINUE READING
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