Crystal structure of nerve growth factor in complex with the ligand-binding domain of the TrkA receptor

@article{Wiesmann1999CrystalSO,
  title={Crystal structure of nerve growth factor in complex with the ligand-binding domain of the TrkA receptor},
  author={C. Wiesmann and M. Ultsch and S. Bass and A. Vos},
  journal={Nature},
  year={1999},
  volume={401},
  pages={184-188}
}
  • C. Wiesmann, M. Ultsch, +1 author A. Vos
  • Published 1999
  • Biology, Medicine
  • Nature
  • Nerve growth factor (NGF) is involved in a variety of processes involving signalling, such as cell differentiation and survival, growth cessation and apoptosis of neurons. These events are mediated by NGF as a result of binding to its two cell-surface receptors, TrkA and p75 (ref. 2). TrkA is a receptor with tyrosine kinase activity that forms a high-affinity binding site for NGF. Of the five domains comprising its extracellular portion, the immunoglobulin-like domain proximal to the membrane… CONTINUE READING
    347 Citations
    Identification and structure of the nerve growth factor binding site on TrkA.
    • 37
    Structural and Mechanistic Insights into Nerve Growth Factor Interactions with the TrkA and p75 Receptors
    • 263
    • Highly Influenced
    • PDF
    TrkA Amino Acids Controlling Specificity for Nerve Growth Factor*
    • 16
    • PDF
    TrkA Immunoglobulin-Like Ligand Binding Domains Inhibit Spontaneous Activation of the Receptor
    • 99
    • Highly Influenced
    • PDF

    References

    SHOWING 1-10 OF 32 REFERENCES
    Growth factor receptors: structure, mechanism, and drug discovery.
    • 71
    Crystal structures of the neurotrophin-binding domain of TrkA, TrkB and TrkC.
    • 162