Crystal structure of nerve growth factor in complex with the ligand-binding domain of the TrkA receptor
@article{Wiesmann1999CrystalSO, title={Crystal structure of nerve growth factor in complex with the ligand-binding domain of the TrkA receptor}, author={C. Wiesmann and M. Ultsch and S. Bass and A. Vos}, journal={Nature}, year={1999}, volume={401}, pages={184-188} }
Nerve growth factor (NGF) is involved in a variety of processes involving signalling, such as cell differentiation and survival, growth cessation and apoptosis of neurons. These events are mediated by NGF as a result of binding to its two cell-surface receptors, TrkA and p75 (ref. 2). TrkA is a receptor with tyrosine kinase activity that forms a high-affinity binding site for NGF. Of the five domains comprising its extracellular portion, the immunoglobulin-like domain proximal to the membrane… CONTINUE READING
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