Crystal structure of momordin, a type I ribosome inactivating protein from the seeds of Momordica charantia.

@article{Husain1994CrystalSO,
  title={Crystal structure of momordin, a type I ribosome inactivating protein from the seeds of Momordica charantia.},
  author={Javed Husain and Ian J. Tickle and Steve P. Wood},
  journal={FEBS letters},
  year={1994},
  volume={342 2},
  pages={154-8}
}
A type I ribosome-inactivating protein, extracted and purified from M. charantia seeds, was crystallised by vapour diffusion with polyethylene glycol at pH 7.2. X-ray data were collected to 2.1 A resolution and the structure solved by molecular replacement using the A-chain coordinates of ricin. The overall fold of the protein is similar to ricin but there are differences in secondary structure, on the surface and in the active site cleft. These differences are probably due in part to the… CONTINUE READING

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