Crystal structure of inositol phosphate multikinase 2 and implications for substrate specificity.

@article{Holmes2006CrystalSO,
  title={Crystal structure of inositol phosphate multikinase 2 and implications for substrate specificity.},
  author={William M. Holmes and Gerwald Jogl},
  journal={The Journal of biological chemistry},
  year={2006},
  volume={281 49},
  pages={38109-16}
}
Inositol polyphosphates perform essential functions as second messengers in eukaryotic cells, and their cellular levels are regulated by inositol phosphate kinases. Most of these enzymes belong to the inositol phosphate kinase superfamily, which consists of three subgroups, inositol 3-kinases, inositol phosphate multikinases, and inositol hexakisphosphate kinases. Family members share several strictly conserved signature motifs and are expected to have the same backbone fold, despite very… CONTINUE READING