Crystal structure of human riboflavin kinase reveals a beta barrel fold and a novel active site arch.

Abstract

Riboflavin kinase (RFK) is an essential enzyme catalyzing the phosphorylation of riboflavin (vitamin B(2)) to form FMN, an obligatory step in vitamin B(2) utilization and flavin cofactor synthesis. The structure of human RFK revealed a six-stranded antiparallel beta barrel core structurally similar to the riboflavin synthase/ferredoxin reductase FAD binding… (More)

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Cite this paper

@article{Karthikeyan2003CrystalSO, title={Crystal structure of human riboflavin kinase reveals a beta barrel fold and a novel active site arch.}, author={Subramanian Vedhanarayanan Karthikeyan and Qingxian Zhou and Faika Mseeh and Nick V. Grishin and A. Osterman and Hong Zhang}, journal={Structure}, year={2003}, volume={11 3}, pages={265-73} }