Crystal structure of human parathyroid hormone 1-34 at 0.9-A resolution.

  title={Crystal structure of human parathyroid hormone 1-34 at 0.9-A resolution.},
  author={Ling Jin and Stephen L. Briggs and Srivari Chandrasekhar and Nickolay Y Chirgadze and David K. Clawson and Richard W. Schevitz and David L. Smiley and Armen H. Tashjian and Fuming Zhang},
  journal={The Journal of biological chemistry},
  volume={275 35},
The N-terminal fragment 1-34 of parathyroid hormone (PTH), administered intermittently, results in increased bone formation in patients with osteoporosis. PTH and a related molecule, parathyroid hormone-related peptide (PTHrP), act on cells via a common PTH/PTHrP receptor. To define more precisely the ligand-receptor interactions, we have crystallized human PTH (hPTH)-(1-34) and determined the structure to 0.9-A resolution. hPTH-(1-34) crystallizes as a slightly bent, long helical dimer… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.


Publications citing this paper.
Showing 1-10 of 26 extracted citations

Prospects of Parathyroid Hormone in Therapeutic Intervention

International Journal of Peptide Research and Therapeutics • 2018
View 1 Excerpt


Publications referenced by this paper.
Showing 1-4 of 4 references

X-PLOR Version 3.1: a System for Crystallography and NMR

A. T. Brunger
View 2 Excerpts
Highly Influenced

Crystal Structure of hPTH-(1–34) 27244 by gest on O cber 28

S. M. Condon, I. Morize, +9 authors R. F. Labaudiniere
J. Am. Chem. Soc. 122, • 2000
View 2 Excerpts

The Parathyroids: Basic and Clinical Concepts (Bilezikian

E. Canalis, J. M. Hock, L. G. Raisz
View 1 Excerpt

E660–E667 Crystal Structure of hPTH-(1–34) 27243 by gest on O cber 28

R. Civitelli, I. R. Reid, S. Westbrook, L. V. Avioli, K. A. Hruska
Am. J. Physiol • 1988
View 1 Excerpt

Similar Papers

Loading similar papers…