Crystal structure of human mono-phosphorylated ERK1 at Tyr204.


Extracellular signal-regulated kinase (ERK) is a member of the MAP kinase family, and can regulate several cellular responses. The isoforms ERK1 and ERK2 have markedly similar amino acid sequences, but exhibit distinctive physiological functions. As well as ERK2, ERK1 was auto- and mono-phosphorylated at Tyr204 in the activation loop during Escherichia coli… (More)
DOI: 10.1016/j.bbrc.2008.10.127