Crystal structure of human mitochondrial NAD(P)+-dependent malic enzyme: a new class of oxidative decarboxylases.

@article{Xu1999CrystalSO,
  title={Crystal structure of human mitochondrial NAD(P)+-dependent malic enzyme: a new class of oxidative decarboxylases.},
  author={Yimeng Xu and Gautam Bhargava and Hao Wu and G{\"u}nter L{\"o}ber and Liang Tong},
  journal={Structure},
  year={1999},
  volume={7 8},
  pages={R877-89}
}
BACKGROUND Malic enzymes catalyze the oxidative decarboxylation of malate to pyruvate and CO2 with the concomitant reduction of NAD(P)+ to NAD(P)H. They are widely distributed in nature and have important biological functions. Human mitochondrial NAD(P)+-dependent malic enzyme (mNAD-ME) may have a crucial role in the metabolism of glutamine for energy production in rapidly dividing cells and tumors. Moreover, this isoform is unique among malic enzymes in that it is a cooperative enzyme, and its… CONTINUE READING

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